Dynamics of strychnine block of single sodium channels in bovine chromaffin cells.
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چکیده
منابع مشابه
Ionic permeation and blockade in Ca2+-activated K+ channels of bovine chromaffin cells
Single channel currents through Ca2+-activated K+ channels of bovine chromaffin cells were measured to determine the effects of small ions on permeation through the channel. The channel selects strongly for K+ over Na+ and Cs+, and Rb+ carries a smaller current through the channel than K+. Tetraethylammonium ion (TEA+) blocks channel currents when applied to either side of the membrane; it is e...
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Different types of calcium channels and secretion from bovine chromaffin cells.
Bovine chromaffin cells possess several types of Ca2+ channels, and influx of Ca2+ is known to trigger secretion. However, discrepant information about the relative importance of the individual subtypes in secretion has been reported. We used whole-cell patch-clamp measurements in isolated cells in culture combined with fura-2 microfluorimetry and pharmacological manipulation to determine the d...
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Nicotine-induced ATP secretion from chromaffin cells was blocked by imipramine and desipramine. This blocking action took place on both, fast and slow, components of ATP secretion. Exposure of chromaffin cells to nicotine (10 microM) for 4 s induced an inward current of about -155 pA. Imipramine and desipramine blocked, in a concentration-dependent manner, both peak inward current and total cha...
متن کاملProton Block of Rat Brain Sodium Channels
The acid titration function of bilayer-incorporated batrachotoxin (BTX)-modified sodium channels was examined in experiments in which the pH was decreased symmetrically, on both sides of the membrane, or asymmetrically, on only one side. In an a t tempt to minimize interpretat ional ambiguities, the experiments were done in 1.0 M NaCI (buffered to the appropr ia te pH) with channels incorporate...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1986
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1986.sp015941